Another Reason BCG Vaccine Was Not Used Against COVID

 Cohort studies demonstrated early on in the pandemic that BCG vaccine would have slowed the advance of COVID and saved millions of lives. Don't ever expect to hear this from the pharmaceutical controlled corporate media mob. But there is another reason for why they didn't want people to get the BCG jab. The BCG vaccine can cure or lessen the damaging effects Type one diabetes. 

Abstract

The bacillus Calmette-Guerin (BCG) vaccine is a microorganism developed as a vaccine for tuberculosis 100 years ago and used as therapy for bladder cancer 40 years ago. More recently, BCG has shown therapeutic promise for type 1 diabetes (T1D) and several other autoimmune diseases. In T1D, BCG restored blood sugars to near normal, even in patients with advanced disease of >20 years duration. This clinically important effect may be driven by resetting of the immune system and the shifting of glucose metabolism from overactive oxidative phosphorylation, a state of minimal sugar utilization, to aerobic glycolysis, a state of high glucose utilization, for energy production. The mechanistic findings support the Hygiene Hypothesis and reveal the immune and metabolic synergy of mycobacterial reintroduction in modern humans.

Keywords: BCG vaccine; TNF; Tregs; aerobic glycolysis; oxidative phosphorylation; type 1 diabetes.

Copyright © 2018 Elsevier Ltd. All rights reserved.

Similar articles

• Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications.

  Shpilsky GF, Takahashi H, Aristarkhova A, Weil M, Ng N, Nelson KJ, Lee A, Zheng H, Kühtreiber WM, Faustman DL.iScience. 2021 Sep 21;24(10):103150. doi: 10.1016/j.isci.2021.103150. eCollection 2021 Oct 22.PMID: 34646988 Free PMC article.
• Benefits of BCG-induced metabolic switch from oxidative phosphorylation to aerobic glycolysis in autoimmune and nervous system diseases.

  Faustman DL.J Intern Med. 2020 Dec;288(6):641-650. doi: 10.1111/joim.13050. Epub 2020 Mar 18.PMID: 32107806 Review.
• TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment.

  Faustman DL.Diabetes Metab Res Rev. 2018 Jan;34(1). doi: 10.1002/dmrr.2941. Epub 2017 Sep 29.PMID: 28843039 Review.
• Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations.

  Kühtreiber WM, Tran L, Kim T, Dybala M, Nguyen B, Plager S, Huang D, Janes S, Defusco A, Baum D, Zheng H, Faustman DL.NPJ Vaccines. 2018 Jun 21;3:23. doi: 10.1038/s41541-018-0062-8. eCollection 2018.PMID: 29951281 Free PMC article.
• Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus.

  Stienstra R, Netea MG.Trends Endocrinol Metab. 2018 Dec;29(12):813-814. doi: 10.1016/j.tem.2018.10.001. Epub 2018 Oct 13.PMID: 30327169

See all similar articles

Cited by 13 articles

• Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications.

  Shpilsky GF, Takahashi H, Aristarkhova A, Weil M, Ng N, Nelson KJ, Lee A, Zheng H, Kühtreiber WM, Faustman DL.iScience. 2021 Sep 21;24(10):103150. doi: 10.1016/j.isci.2021.103150. eCollection 2021 Oct 22.PMID: 34646988 Free PMC article.
• The Role of Pediatric BCG Vaccine in Type 1 Diabetes Onset.

  Doupis J, Kolokathis K, Markopoulou E, Efthymiou V, Festas G, Papandreopoulou V, Kallinikou C, Antikidou D, Gemistou G, Angelopoulos T.Diabetes Ther. 2021 Nov;12(11):2971-2976. doi: 10.1007/s13300-021-01163-2. Epub 2021 Oct 1.PMID: 34596880 Free PMC article.
• Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence.

  Dow CT.Front Immunol. 2021 Aug 5;12:714179. doi: 10.3389/fimmu.2021.714179. eCollection 2021.PMID: 34421917 Free PMC article. Review.
• BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation.

  Keefe RC, Takahashi H, Tran L, Nelson K, Ng N, Kühtreiber WM, Faustman DL.Sci Rep. 2021 Jul 22;11(1):14933. doi: 10.1038/s41598-021-94529-2.PMID: 34294806 Free PMC article.
• On BCG Vaccine Protection from COVID-19: A Review.

  Bagheri N, Montazeri H.SN Compr Clin Med. 2021 Mar 15:1-11. doi: 10.1007/s42399-021-00835-1. Online ahead of print.PMID: 33748676 Free PMC article. Review.

See all "Cited by" articles

Therapeutic Effects of BCG Vaccination on Type 1 Diabetes ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139880

Mar 26, 2020 · Type 1 diabetes mellitus (T1DM) causes the irreversible destruction of pancreatic beta cells. The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression. The aim of this study is to investigate the efficacy of the BCG vaccine for the treatment of T1DM.

• Cited by: 3
• Publish Year: 2020

• Author: Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu, Hsin-Yin Hsu

ADA 2021: update further demonstrates the use of the BCG ...

https://www.clinicaltrialsarena.com/comment/ada-2021-bcg-vaccine-t1d

Jun 30, 2021 · At the 81 st Scientific Sessions of the American Diabetes Association (ADA) annual meeting, researchers from Massachusetts General Hospital (MGH) presented an update on their trials of the Bacillus Calmette-Guerin (BCG) vaccine as a treatment for type 1 diabetes (T1D). The presentation (abs: 1142-P) included an increased understanding of how the age of …

BCG Therapy for Type 1 Diabetes: Restoration of Balanced ...

https://pubmed.ncbi.nlm.nih.gov/30600132

BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism. The bacillus Calmette-Guerin (BCG) vaccine is a microorganism developed as a vaccine for tuberculosis 100 years ago and used as therapy for bladder cancer 40 years ago. More recently, BCG has shown therapeutic promise for type 1 diabetes (T1D) and several other autoimmune …

• Cited by: 23
• Publish Year: 2019

• Author: Willem M. Kühtreiber, Denise L. Faustm